Bart: Who the hell is that?
Homer: Bullwinkle.
Bart: Who? Wait a minute, who’s that?
Homer: Underdog, don’t you know anything?
Bart: It wouldn’t hurt them to use some cartoons made in the last fifty years.
Homer: Bart, this is the tradition. If you build a balloon for every flash in the pad cartoon character, you’ll turn the parade into a farce.
(A Bart balloon shows up on the television)
Johnny Depp is one of my biggest inspirations!
Megamind: (talking to a Drinking Bird toy) I know. Funny. Always thirsty, never satisfied. I understand you, little well dressed bird. Purposeless, emptiness. It’s a vacuum, isn’t it? It’s… What’s your vacuum like?
Minion: (bursts in with the Venus de Milo statue) I’m going off the rails on a crazy train, sir!
Megamind: Hey, not now, Minion! I’m in a heated, existential discussion with this dead-eyed, plastic desk toy.
-Megamind
Dr. Hibbert: Now, a little death anxiety is normal. You can expect to go through five stages. The first is denial.
Homer: No way! Because I’m not dying!
Dr. Hibbert: The second is anger.
Homer: Why, you little…
Dr. Hibbert: After that comes fear.
Homer: [cringing] "What’s after fear? What’s after fear?
Dr. Hibbert: Bargaining.
Homer: Doc, you gotta get me out of this! I’ll make it worth your while!
Dr. Hibbert: Finally, acceptance.
Homer: Well, we all gotta go sometime.
Dr. Hibbert: Mr. Simpson, your progress astounds me.
(Opening monologue) “Here’s my day so far: went to jail, lost the girl of my dreams and got my butt kicked pretty good. Still, things could be a lot worse. Oh, that’s right… I’m falling to my death. Guess they can’t.”
Barney: Hey, Homer, you’re late for English!
Homer: Pffft, English. Who needs that. I’m never going to England.
Megamind: (to Minion) You dim-witted creation of science!
Roxanne (on phone) Um, what?
Megamind: Oh uh, not you, I was yelling at my Mothers Urn…
-Megamind
“Speak to me of summer, long winters longer than time can remember,
Setting up of other roads, travel on in old accustomed ways.
I still remember the talks by the water, the proud sons and daughters,
That in the knowledge of the land, spoke to me in sweet accustomed ways.”
Marge: My quilt! Six generations, ruined! (Sobs)
Homer: Now, Marge, honey. Honey, honey. Come on. Come on. Don’t get upset. It’s not the end of the world. We all loved that quilt, but you can’t get too attached to–
(Homer sees the remains of his cookie.)
Homer: My cookie! Oh, this is not happening. This is not happening!
Megamind: YOU! Yes you! Bring out… THE BLACK MAMBA!
-Megamind
Homer: I’m a big fat pig!
Marge: Now Homer, you do have big bones.
Homer: Marge, nobody gains 30 pounds of bone!
Hal/Titan: “NO! FREAKIN! WAY!”
-Megamind
“Well, you know what I think? I think Casper is the ghost of Richie Rich”
Bart Simpson.
SOA 
Megamind: All men must choose between two paths. Good is the path of honour, heroism, and nobility. Evil… well, it’s just cooler.
What?
“A hundred bucks?! For a comic book! Who drew it, Micha laman gelo?”
Homer Simpson.
“Science is not good or bad, Victor. But it can be used both ways. That is why you must always be careful.”
—Mr. Rzykruski, Frankenweenie
“Hello Jerry? This is Homer Simpson. Remember last month when I paid back that loan? Yeah, well now I need you to do a favor for me!”
Homer Simpson
The Richie Rich and Casper pic… Its true!
Jack Frost: Am I on the Naughty List?
North: Naughty List, you hold record.
-Rise of The Guardians
Milhouse: Bart, my mom won’t let me be your friend any more. That’s why you couldn’t come to the party.
Bart: What’s she got against me?
Milhouse: She says you’re a bad influence…
Bart: Bad influence my foot! How many times have I told you: never listen to your mother!
Poppy: When the headgirl has earned my respect, then I will shake her hand, biatch!
Harriet: I’m sorry?
Poppy: Apology accepted
-Wild Child
“A man who envies our family is a man who needs help.”
Lisa Simpson